Lupus erythematosus
☆ 2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
اهو ٿورڙي جامني رنگ جي erythema وانگر ظاهر ٿئي ٿو.
تتل فلائي ريش جيڪا عام طور تي منهن تي ظاهر ٿئي ٿي.
References
سڃاڻپ ۽ درجه بندي cutaneous lupus erythematosus (CLE) تشخيصي چئلينج کي منهن ڏئي ٿو، ان کي چمڙي جي شموليت سان systemic lupus erythematosus کان فرق ڪرڻ. تازو مطالعو جينياتي، ماحولياتي، ۽ امونولوجيڪل عنصرن تي روشني وجهي ٿو CLE جي تحت. دوا جي شموليت خاص طور تي ظاهر ڪيو ويو آهي CLE لاء سڀ کان اهم محرڪن مان. علاج ۾ بنيادي ۽ سسٽماتي علاج شامل آهن، جن ۾ واعدو ڪندڙ حياتيات (belimumab, rituximab, ustekinumab, anifrolumab, BIIB059) شامل آهن، ڪلينڪل آزمائشي ۾ ڪارڪردگي جو مظاهرو ڪيو ويو آهي.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) مختلف چمڙي جي مسئلن کي ڍڪيندو آهي، جن مان ڪجهه شايد وسيع صحت جي مسئلن سان ڳنڍيل هوندا. اهو مختلف قسمن ۾ ورهايل آهي، جهڙوڪ acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE تي مشتمل آهي discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus آٽو ايميون بيمارين جو هڪ گروپ آهي جيڪو جسم جي مختلف حصن کي متاثر ڪري سگهي ٿو. ڪجهه قسم، جهڙوڪ systemic lupus erythematosus (SLE) ، ڪيترن ئي عضون کي متاثر ڪن ٿا، جڏهن ته ٻيا، جهڙوڪ cutaneous lupus erythematosus (CLE) ، خاص طور تي چمڙي کي متاثر ڪن ٿا. اسان CLE جي مختلف قسمن کي ڪلينڪل نشانين، ٽشو امتحان، ۽ رت جي ٽيسٽ جي ميلاپ جي بنياد تي درجه بندي ڪريون ٿا، پر ماڻهن جي وچ ۾ تمام گهڻو فرق آهي. چمڙي جا مسئلا اڪثر سببن جي ڪري پيدا ٿين ٿا جهڙوڪ سج جي روشني، سگريٽ نوشي، يا ڪجهه دوائن جي نمائش.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus جو سبب واضح ناهي. هڪجهڙا جڙيل ٻارن ۾، جيڪڏهن هڪ متاثر ٿئي ٿو ته 24 سيڪڙو امڪان آهي ته ٻيو هڪ به ٿيندو. عورتن جي جنسي هارمون، سج جي روشني، سگريٽ نوشي، وٽامن ڊي جي گھٽتائي، ۽ ڪجهه انفيڪشن پڻ خطري کي وڌائڻ جو يقين آهي.
علاج ۾ شامل ٿي سگھي ٿو NSAIDs، corticosteroids، immunosuppressants، hydroxychloroquine، ۽ methotrexate. جيتوڻيڪ corticosteroids اثرائتو آھن، ڊگھي مدت جي استعمال جا نتيجا ضمني اثرات ۾.